AKTIVITAS ANTIHIPERURISEMIA EKTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) PADA MENCIT JANTAN HIPERURISEMIA
نویسندگان
چکیده
Hiperurisemia adalah peningkatan kadar asam urat darah di atas normal. terjadi akibat meningkatnya produksi atau menurunnya pembuangan urat, kombinasi keduanya. Asam merupakan hasil akhir metabolisme purin dalam tubuh. Penyakit gout gangguan inflamasi akut yang ditandai dengan pembengkakan pada sendi disebabkan tinggi (hiperurisemia). Salah satu tanaman dapat digunakan sebagai obat tradisional untuk hiperurisemia daun pandan wangi (Pandanus amaryllifolius Roxb.). Tujuan penelitian ini mengetahui aktivitas antihiperurisemia ekstrak etanol dari terhadap mencit jantan hiperurisemia.Tiga puluh ekor dibagi menjadi enam kelompok yaitu kontrol normal, negative (diberi jus hati sapi 0,6 ml/20gBB), positif (alopurinol 13 mg/kgBB), dosis 200 mg/kgBB, 400 mg/kgBB dan 800 mg/kgBB.Penginduksian dilakukan menggunakan Makanan Diet Purin (MDPT) segar. Pemeriksaan metode Point of Care Testing (POCT) alat digital EasyTouch®GCU. Hasil didapat Roxb.) 200mg/kgBB, 400mg/kgBBdan menurunkan putih secara signifikan (P<0,05). Potensi mg/kgbb setara allopurinol (P>0,05).
منابع مشابه
Optimization of Reflux Conditions for Total Flavonoid and Total Phenolic Extraction and Enhanced Antioxidant Capacity in Pandan (Pandanus amaryllifolius Roxb.) Using Response Surface Methodology
Response surface methodology was applied to optimization of the conditions for reflux extraction of Pandan (Pandanus amaryllifolius Roxb.) in order to achieve a high content of total flavonoids (TF), total phenolics (TP), and high antioxidant capacity (AC) in the extracts. Central composite experimental design with three factors and three levels was employed to consider the effects of the opera...
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ژورنال
عنوان ژورنال: Jurnal Ilmiah Farmako Bahari
سال: 2022
ISSN: ['2087-0337', '2715-9949']
DOI: https://doi.org/10.52434/jfb.v13i2.1223